Aphidicolin

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Aphidicolin is Reversible inhibitor of eukaryotic nuclear DNA replication. Aphidicolin is defined as Tetracyclic diterpene with antiviral and antimitotic properties. Specific inhibitor of (alpha)-type polymerase (eucaryotic and viral coded)

Aphidicolin Chemical Name: : (3-alpha,4-alpha,5-alpha,17-alpha)-3,17-Dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol

Aphidicolin Molecular Formula: C₂₂H₃₇NO₅

Aphidicolin 2D formula

 

 

Aphidicolin references

1. Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients.

2. Localisation of aphidicolin -induced break points in Holstein-Friesian cattle (Bos taurus) using RBG-banding

3. Defective neurite outgrowth in aphidicolin/cAMP-induced motor neurons expressing mutant Cu/Zn superoxide dismutase

4. Expression of folate sensitive and aphidicolin induced chromosomal fragile sites in familial neuroblastoma

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